https://www.ijhcr.com/index.php/ijhcr/issue/feed International Journal of Health and Clinical Research 2024-10-22T11:54:06+00:00 James editor@ijhcr.com Open Journal Systems <p style="text-align: justify;">International Journal of Health and Clinical Research (IJHCR) is an open-access; freely accessible, online and print monthly peer-reviewed international journal publishes a wide spectrum of advanced research on all medical specialties including ethical and social issues. IJHCR is a gateway to enlighten the latest research/issues happening all around the world of medical and health sciences.</p> <p style="text-align: justify;">The journal publishes Original research articles in the form of full-length papers or short communications especially those with multidisciplinary nature. The journal welcomes review articles, mini-reviews, case reports, letter to the editor, guest editorial or commentaries.</p> https://www.ijhcr.com/index.php/ijhcr/article/view/5476 Formulation and evaluation of fast dissolving tablet-bilastine 2024-10-22T11:35:49+00:00 Mohit Changra Changra@gmail.com Satinder Kakkar Kakkar@gmail.com Ramandeep Singh Singh@gmail.com <p>In the present, study to establish Fast dissolving tablets of Bilastine by using different ratio of superdisintegrants. The tablets were prepared by using two superdisintegrants( croscarmellose sodium, sodium starch glycolate) in different composition. Development of Fast dissolving tablets of Bilastine were designed to give rapid onset of action and help those patients who have difficulty in swallowing the drug . The present study aims to improve patient compliance, reduce the condition of dysphagia and also reduces the multiple dosing. Tablets were evaluated by different parameters such as Weight variation, Tablet hardness, Friability ,Mouth feel ,Wetting time, Water absorption ratio, In vitro drug release study, In vitro disintegration time, Drug content uniformity, Accelerated stability testing. The present study concludes that fast dissolving tablets of Bilastine with different composition of superdisintrgants shows rapid disintregation time as well as dissolution profile which represents rapid onset of action of the formulation.</p> 2024-10-22T00:00:00+00:00 Copyright (c) 2024 Mohit Changra, Satinder Kakkar, Ramandeep Singh https://www.ijhcr.com/index.php/ijhcr/article/view/5474 Morphological variations in Common Facial Vein with variant venous drainage 2024-10-22T11:02:43+00:00 M Tejvirat Tejvirat@gmail.com Rahul Jha Jha@gmail.com Aseem Tandon Tandon@gmail.com Debasis Bandyopadhyay Bandyopadhyay@gmail.com VDS Jamwal Jamwal@gmail.com Subhash B Subhash@gmail.com <p>Background: In depth anatomical knowledge of the facial vasculature is crucial not only for anatomists but also for Oto-rhino-laryngologists, reconstructive and oral and maxillofacial surgeons. The common facial vein (CFV) is a vital component of the facial venous system, which exhibits morphological variations that impact surgical and diagnostic procedures. The present study investigates the CFVs anatomical diversity, focusing on the divergent venous drainage patterns. Aim: To describe rare anatomical variations of the common facial vein. Material and Methods: The study was conducted in the Department of Anatomy, of a tertiary care establishment (Medical College) in Western Maharashtra, during the period 2023-24. Head and neck region of 20 cadavers (11 males and 9 females) i.e. 40 sides of embalmed cadavers of different age group were carefully dissected, and studied for variations in the formation and drainage pattern of Common facial vein. Results: In 34 sides (85 %), the common facial vein (CFV) terminated into the Internal jugular vein (IJV) as per standard anatomic description. On one side of the cadaver, the left common facial vein (2.5%) was found draining into the anterior jugular vein (AJV) as well as into the internal jugular vein (IJV). In three cadavers (7.5%), the CFV was found to be draining into the AJV. In two cadavers (5%), the facial vein (FV) was not receiving the anterior division of retromandibular vein and was directly draining into the IJV. Conclusion: A sound knowledge of variation in the course and termination of common facial vein is very useful for the clinicians and surgeons who perform procedures like cannulation and vein graft harvesting for endarterectomies of the head and neck region.</p> 2024-10-22T00:00:00+00:00 Copyright (c) 2024 M Tejvirat, Rahul Jha, Aseem Tandon, Debasis Bandyopadhyay, VDS Jamwal, Subhash B