International Journal of Health and Clinical Research 2024-06-11T04:35:28+00:00 James Open Journal Systems <p style="text-align: justify;">International Journal of Health and Clinical Research (IJHCR) is an open-access; freely accessible, online and print monthly peer-reviewed international journal publishes a wide spectrum of advanced research on all medical specialties including ethical and social issues. IJHCR is a gateway to enlighten the latest research/issues happening all around the world of medical and health sciences.</p> <p style="text-align: justify;">The journal publishes Original research articles in the form of full-length papers or short communications especially those with multidisciplinary nature. The journal welcomes review articles, mini-reviews, case reports, letter to the editor, guest editorial or commentaries.</p> A brief overview on transdermal patches and marketed preparations 2024-06-11T04:05:32+00:00 Abhinav Sharma Satinder Kakar <p>Transdermal drug delivery systems, sometimes referred to as "patches," have significantly improved patient outcomes by offering the benefit of a relatively painless method of administering medication through the skin to provide a systemic effect. Benefits of these patches include regulated medication release, convenience of usage, and avoiding first-pass metabolism. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body.The review gives valuable information about the transdermal patch like its advantage, disadvantage, types of transdermal patch, factors basic components, methods, evaluation, technologies and marketed products .</p> 2024-02-10T00:00:00+00:00 Copyright (c) 2024 Abhinav Sharma, Satinder Kakar Pattern of ocular comorbidities in patients presenting with cataract in a tertiary eye care hospital 2024-06-11T04:15:02+00:00 Avleen Kaur <p>Introduction: Cataract is a slowly progressing eye condition marked by clouding of the normally clear lens of the eye or its capsule that prevents light from entering the eye. Ocular comorbidities are collections of eye conditions that exist simultaneously, regardless of their etiopathogenic relationship. Ocular comorbidities are frequently associated with reduced quality of life and disabilities caused by visual impairment. Aim: To determine the pattern of ocular comorbidities in patients presenting with cataract in a tertiary eye care hospital. Material and methods: This hospital based observational study was conducted in the OPD of the Department of Ophthalmology, Government Medical College Jammu over a period of 1 year from November 2021 to October 2022. A total of 500 patients were included in this study. Data was collected using a clinical proforma and analysed using SPSS inc., v.16. Results: The present study found majority of the participants 195(39.0%) in the age group of 61-70 years with female to male ratio of 1.15:1. Diabetic retinopathy was the most commonly associated ocular comorbidity seen in 5.5% of cataract patients. (5.4% R/E and 5.6% L/E). Conclusion: Adequate control of coexisting ocular diseases is of utmost importance in order to avoid any intraoperative or postoperative problems, anticipating visual outcomes and improving visual results postoperatively by taking necessary steps wherever possible.</p> 2024-02-10T00:00:00+00:00 Copyright (c) 2024 Avleen Kaur An analytical cross-sectional study on the impact of Clinical profile on the Outcome of patients on Mechanical Ventilation at a Tertiary care centre 2024-06-11T04:21:39+00:00 P. Maneesha K. Sri Prabhatha B. Neeharika <p>Introduction: Mechanical ventilation (MV) is an invasive life supporting device to mimic the respiratory physiological function at the time of impending respiratory failure. There is dramatic improvement in the survival of critically ill patients, but also associated with complications affecting the overall outcome. A part from the severity of underlying disease, MV and care related parameters also influence the outcome. Aim: To determine the outcome of mechanically ventilated patients in an ICU depending on their clinical profile. Materials and Method: Retrospective cross sectional study for duration of 6 months. Inclusion criteria: Patients &gt;18years of age, male and female patients, All patients requiring MV support for &gt;12hours, Patients with failing respiratory drive or who failed O2 therapy and NIV are eligible for the study. Exclusion criteria: Patients &lt;18years of age, Patients who died within12 hours of intubation, Patients who were extubated &lt;12 hours of intubation, Pregnant and lactating women, patients with Incomplete data. Conclusion: Increased mortality observed in patients with sepsis and more number of ventilator days and increased length of hospital stay.</p> 2024-02-10T00:00:00+00:00 Copyright (c) 2024 P. Maneesha, K. Sri Prabhatha, B. Neeharika “A Prospective Observational Study Assessing the Morbidity Outcomes of Late Preterm Neonates” 2024-06-11T04:30:09+00:00 Rahul Banti Rohit Bhandar Sharan Deshmukh Aishwarya Bijapure <p>Background &amp; Objectives: To study on early neonatal morbidities in late preterm neonates admitted to neonatal intensive care (NICU).<br>Methods: All late preterm babies (34 0/7weeks-36 6/7 weeks) admitted to neonates who meet the inclusion criteria were studied for a period of 1st October 2019 to 31st March 2021. The infants in the sample were followed throughout their stay in the neonatal intensive care unit (NICU), up until hospital discharge. All the data was collected from infants' and mothers' medical records and at the time of the discharge. Short-term outcomes such as neonatal morbidities, mortality, hospitalization and also maternity risk factors were assessed. Result: A total of 103 late preterm and term neonates were included in the study. Male preponderance was noticed with a ratio of 1.2:1. Majority of the neonates were born with birth weight of more than 2 kg. PROM and previous history of LSCS forms the major maternal risk factor for preterm. This study confirmed that late-preterm infants are a population at risk of increased neonatal morbidity. Neonatal Hyperbilirubinemia requiring phototherapy forms the major one followed by respiratory distress, sepsis and feed Intolerance. Duration of hospital stay also prolonged in late preterm. Majority of late preterm neonates required more than 7 days of hospital duration. Mortality rate and the rate of rehospitalization were also high. Conclusion: Late-preterm infants are therefore a high-risk group of children and need special attention. Immaturity is the major factor contributing to adverse morbidities. Further research is required to develop specific guidelines and protocols to reduce neonatal late preterm mortalities and morbidities.</p> 2024-02-10T00:00:00+00:00 Copyright (c) 2024 Rahul Banti, Rohit Bhandar, Sharan Deshmukh, Aishwarya Bijapure Effectiveness of Physiotherapy and Physical Rehabilitation in the Treatment of Chronic Hemophilic Arthropathy: A Prospective Study From a Comprehensive Hemophilia Care Center in Eastern India 2024-06-11T04:35:28+00:00 Prakas Kumar Mandal Debasis Gantait Kaustav Ghosh Malini Garg <p>Hemophilia is a blood-clotting disorder caused by a deficiency in factor VIII (FVIII) or factor IX (FIX), which manifests itself through bleeding in the muscles and joints. Haemophilic arthropathy causes pain and deterioration in movement, thereby causing disability and permanent joint damage. Aim of the study was to determine the effect of physiotherapy on range of motion on target joints in people with hemophilia. This was a prospective study done on 50 patients of all age groups with hemophilia in the study period from March 2022 to February 2023</p> 2024-02-10T00:00:00+00:00 Copyright (c) 2024 Prakas Kumar Mandal, Debasis Gantait, Kaustav Ghosh, Malini Garg