Comparative evaluation of Ondansetron and Granisetron in combination with Dexamethasone for the prophylaxis of chemotherapy and radiation induced emesis in cervical cancer patients: A prospective study

Authors

  • Saroj Kothari Professor and Head, Department of Pharmacology, Gajra Raja Medical College Gwalior, Madhya Pradesh, India
  • Surabhi Porwal Assistant Professor, Department of Obstetrics and Gynaecology, MGM Medical College Indore, Madhya Pradesh, India
  • CM Gupta P.G. Resident, Department of Pharmacology, Gajra Raja Medical College Gwalior, Madhya Pradesh, India
  • AK Nigam Professor and Head, Department of Radiation Oncology, Gajra Raja Medical College Gwalior, Madhya Pradesh, India

Keywords:

Antiemetics, Chemotherapy, Radiotherapy, Ondansetron, Granisetron.

Abstract

Background: In advanced stages of cervical cancer, neoadjuvant chemoradiation have been used to improve the survival rates. Chemotherapy and radiotherapy induced emesis is severe adverse effect observed in cancer patients. There isstrong need to control nausea and vomiting, so that patients have better quality of life and adherence to treatment. Objective: present study plan to compare the efficacy of Ondansetron and Granisetron in combination with Dexamethasone in the prophylaxis of chemotherapy and radiation induced emesis in cervical cancer patients. Methods: This is a prospective study conducted from March 2019 to August 2020 in Jaya Arogya hospital, Gwalior. Cervical cancer patients were admitted for concurrent chemoradiation (Cisplatin monotherapy and half body irradiation). Total 100 cervical cancer patients included in study.Among them 50patients were administeredOndansetron and Dexamethasone and rest 50 patients were given Granisetron and Dexamethasone for prevention to chemothrapy or radiotherapy induced nausea and vomiting. Efficacy of antiemetics was assessed using multinational association of supportive care in cancer antiemesis tool and severity graded by Common Terminology Criteria for Adverse Events. Results: The study showed that 46% patients experienced nausea, 30% experienced vomiting who received Granisetron plus Dexamethasone whereas 64% experienced nausea, 46% experienced vomiting who received Ondansetron plus Dexamethasone. 36%, 20%, 8% patients in group1 and 30%, 12%, 4% patients in group2 experienced mild, moderate and severe nausea respectively whereas 28%, 14%, 4% patients in group1 and 22%, 6%,2% patients from group2 experienced mild, moderate and severe vomiting respectively. Conclusion: Present study showed that prophylactic use of Granisetron is more efficacious than Ondansetron for controlling chemotherapy and radiation induced nausea and vomiting.

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Published

2021-06-16

How to Cite

Saroj Kothari, Surabhi Porwal, CM Gupta, & AK Nigam. (2021). Comparative evaluation of Ondansetron and Granisetron in combination with Dexamethasone for the prophylaxis of chemotherapy and radiation induced emesis in cervical cancer patients: A prospective study. International Journal of Health and Clinical Research, 4(11), 23–27. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/1722