Role of Neutral pH Super Oxidised Solution in Diabetic Foot Ulcers

Abstract

Background:Chronic wounds in the background of infection require long term treatment with various dressing. The study was done to evaluate role of commonly used topical solutions in the management of Diabetic foot ulcers.Aims and Objectives:To compare the efficacy of neutral pH super oxidised solution (SOS) versus .Povidone Iodine (PI) in the management of diabetic foot ulcers. Methods:Prospective study of patients with Diabetic Foot ulcers admitted in ESIC MC and PGIMSR Rajajinagar,Bengaluru between Jan 2019 to June 2020 , satisfying the inclusion criteria were randomized into 2 groups. Super Oxidised Solution group and Povidone Iodine group had 100 patients each. Wound assessments done at regular intervals and various wound outcome variables compared. Statistical analysis of data done using chi square test, independent student t test, 1-way ANOVA, post hoc Bonferroni correction and Pearsons correlation. Results:In a study of 200 patients, most patients were in the age group of 51-60years, and 75.5% were males. There was 35% decrease in wound size in SOS group compared to 20% in PI group at day 21, and earlier appearance of granulation and epithelialization in SOS group. Resolution of periwound erythema and periwoundedema was earlier in SOS group compared to PI Group. There was shorter duration of hospital stay, earlier wound disinfection and more number of patients who underwent skin grafting before 21 days in SOS group compared to PI group. Conclusion:Super oxidised solution has faster response in wound healing and gives better efficacy as compared to the traditional Povidone Iodine solution for use in wound care in management of lower limb ulcers.