A study of Multi Drug Resistant UTI caused by Klebsiella Oxytoca

Abstract

Background:Klebsiella oxytoca is one among the several Klebsiella species that are opportunistic pathogens that cause a wide spectrum of severe diseases. This bacteria is naturally found in the intestinal tract, mouth and nose. Outside the gut, however these bacteria can cause serious infection. Klebsiella oxytoca is emerging as an important bacterial isolate causing urinary tract infections in adults and having multiple drug resistance to commonly used antibiotics. It is a gram-negative pathogen, cylindrical rod shaped and non-motile in nature.Aim and objective: To study multi drug resistant urinary tract infection caused by Klebsiella oxytoca.Material and methods: The urinary samples were inoculated on CLED and MacConkey agar. Further identification was done as per routine laboratory protocols. Antibiotic susceptibility testing was done in accordance with Clinical and Laboratory Standard Institute (CLSI) guidelines. Antibiotics disks included in this study by Kirby–Bauer's disk diffusion method. Collected samples were processed at Department of Microbiology, PMCH, Patna.Results: We analyzed our data to observe the current pattern of drug resistance among Klebsiella Oxytoca isolated from urinary samples from the period of March 2020 to April 2021 at Patna Medical College Hospital, Patna. A total of 15,200 samples were processed at the hospital laboratory during this period. Klebsiella species were isolated from 510 of these clinical samples Out of these, 480 were Klebsiella pneumoniae and 30 were Klebsiella Oxytoca. These isolates showed 62% of resistance to Imipenem and Meropenem. The resistance to Gentamicin and Amikacin was 62%. Resistance to Ciprofloxacin, Levofloxacin, Moxifloxacin and Aztreonam were 45%. The data from our study showed an increasing burden of infection caused by this bacteria. It is recommended that Hospital Infection Control Committee must keep a close watch on the antibiotic pattern of KlebsiellaOxytoca for better patient care.Conclusion: K. Oxytoca species are rapidly developing multi drug resistance in UTI. Earlier it was only Pseudomonas and Acinetobacter that showed high resistance to commonly used antibiotics. UTI caused by multidrug resistant bacteria pose a serious threat to public health and economy. A society without working antibiotics would be like returning to era when a small injury or infection could easily become a threat to life. It is recommended that hospital infection control committee must keep a close watch on the antibiotic pattern of Klebsiellaoxytoca of better patient care and genomic surveillance focus should remain a priority in the hospital environment.