Anti-nociceptive activity of Aloe vera gel extract in graded doses by using Hot water bath in Albino rats

Abstract

Background: Pain has been described by the International Association for the Study of Pain as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Objective: To evaluate anti-nociceptive activity of Aloe vera gel extract in graded doses by using Hot water bath in Albino rats. Materials and methods: The present study was conducted in the Department of Pharmacology, Kamineni Institute of Medical Sciences (KIMS) from October 2012 - September 2014. It is undertaken to evaluate the anti-nociceptive effect of Aloe vera in animal models of pain in Albino rats. Results:Aloe vera in the doses of 200mg/kg and 400mg/kg orally produced significant anti-nociceptive effect in comparison to control group (DW).The standard drug tramadol in the dose of 20mg/kg orally also produced significant anti-nociceptive effect in comparison to control group (DW). Maximum possible effect in percentage (MPE%) was calculated at 120 min with Aloe vera 400mg/kg and Tramadol 20mg/kg and it was observed that Tramadol 20mg/kg produced more MPE% (90.63 ± 2.32; 77.93 ±2.35; 33.94 ± 1.29 respectively) in comparison to Aloe vera 400mg/kg (80.16 ± 2.27; 46.86 ± 1.75; 21.97 ± 1.01 respectively) indicating Tramadol is more potent than Aloe vera. Conclusion:L Aloe vera leaf gel extract powder (dissolved in distilled water) possesses anti-nociceptive activity at 200 mg/kg and 400 mg/kg dosage at 60, 90 and 120 minutes when given orally in in albino rats.