Atypical manifestations of MIS-N associated with asymptomatic maternal prenatal SARS COV-2 infection -A case series

Authors

  • Tejaswi Reddy DM post graduate in Department of Neonatology, Niloufer Hospital, Hyderabad, Telangana, India
  • Paramesh Pandala Assistant Professor of Pediatrics, Niloufer Hospital, Hyderabad, Telangana, India
  • Mallareddy Ponnathota Assistant Professor of Pediatrics Niloufer Hospital , Hyderabad, Telangana, India
  • Alimelu Madireddy Professor of Neonatology, Niloufer Hospital, Hyderabad, Telangana, India
  • Rakesh Kotha Associate Professor of Neonatology, Niloufer Hospital, Hyderabad, Telangana, India

Abstract

As we know COVID-19, caused by SARS-CoV-2, is a global public health crisis. Due to the lack of viral receptors in children's lungs and placenta, children and newborns are fortunately less affected. But sometimes maternal antibodies may cause severe inflammation in neonates in the form of  Multisystem inflammatory syndrome (MIS-N). Spike protein antibodies which are usually increased after immunization are protective. These antibodies cross the placenta to provide passive immunity to the newborn. Autoantibodies against endothelial, gastrointestinal, and immune cells are may potentially play a role in MIS-N. Here we are presenting atypical presentations of MIS-N. The role of genetic susceptibility in the pathogenesis of MIS-N needs further investigation.

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Published

2021-08-30

How to Cite

Tejaswi Reddy, Paramesh Pandala, Mallareddy Ponnathota, Alimelu Madireddy, & Rakesh Kotha. (2021). Atypical manifestations of MIS-N associated with asymptomatic maternal prenatal SARS COV-2 infection -A case series. International Journal of Health and Clinical Research, 4(15), 397–399. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/2586