A Cross-Sectional Study On Prevalence Of ESBL(Extended Spectrum Beta Lactamases) Producing Gram Negative Bacilli Isolated From Post-Operative Wound Infection At A Tertiary Care Center In Bihar

Abstract

Introduction: Antimicrobial resistance is emerging as one of the major public health threats at the beginning of the 21st century worldwide. The accelerated emergence of antibiotic resistance among the prevalent pathogens is the most serious threat to the management of infectious diseases. Methodology: This cross-sectional study was carried out in the Department of Microbiology, Darbhanga Medical College, during the period of August 2020 to july 2021. Samples were collected after taking informed written consent from patients admitted in different wards of the hospital. Results: A total 103 samples of wound swab & pus from different patients were studied, of which 94 (91.3%) bacterial strains were isolated & 9(8.7%) found no growth. Among the 94 bacterial isolates 75 (79.8%) were gram negative and 19 (20.2%) were Gram-positive. Out of gram-negative species, majority were Klebsiella species 18(24.0%) followed by E. Coli 18(24.0%) and Pseudomonas species 16(21.3%). Conclusion: Existing of extended spectrum β-lactameses in bacteria and their potential multidrug resistance will create serious problem in the future as their continuous mutation and limited therapeutic option. Indiscriminate use of antibiotics especially 3rd generation cephalosporins and monobactams should be avoided. The regular detection of ESBLs producing organisms should be carried out in every laboratory.