A study of vitamin d and thyroid profile to evaluate infertility in females

Abstract

Aim & Objective: To study the serum levels of vitamin D and thyroid profile to evaluate infertility in females. Methodology: The present study was done at Gandhi Hospital, Secunderabad, after approval by Institutional ethical committee of Gandhi Hospital, Secunderabad. All infertility patients with history of not conceiving after 12 months of regular intercourse, without any comorbidities like Hypertension, Diabetes, Heart diseases attending infertility outpatient of Gandhi hospital were enrolled in this study after taking consent. This study was conducted on 50 infertile female cases and 100 fertile controls, in which serum vitamin D and thyroid profile is assayed in Siemens Advia centaur xpt autoanalyzer based on chemiluminescence technique. Results: In the present study it was found that 48% of infertility cases belong to age group 32-39 years with mean±SD of age in infertility cases was 30.06±6.34 and controls was 28.6±6.31. In the present study distribution of vitamin D deficiency was mild 20%, moderate 32% and severe 22% in infertile cases, whereas distribution of vitamin D deficiency in fertile females was mild 33%, moderate 6%, severe 2% indicating majority of moderate and severe vitamin D deficiency belongs to cases. vitamin D mean ±SD of controls was 20.5±6.43 with highly significant p value <0.01 showing vitamin D deficiency is common in infertility cases. In this study distribution of vitamin D deficiency is more prevalent in infertile cases 74% compare to 41% of controls suggest vitamin D role in reproduction. In present study mean±SD of T3 0.74±0.53 in cases, 0.95±0.24 in controls, mean ±SD T4 is 5.06±3.56 in cases ,6.43±2.04 in controls, mean ± SD of TSH is 6.40±4.02 in cases ,3.68±1.02 in controls with significant p value<0.05.Thus indicating altered thyroid profile can result in infertility. Hypothyroidism constitute about 50% of infertility cases, hyperthyroidism was 8% and euthyroid was 42%. Vitamin D deficiency is more commonly seen in hypothyroid cases 91.6%. Conclusion: This study shows negative correlation between vitamin D and TSH levels in infertility which need to be further evaluated. Hence all patients of female infertility should be screened for vitamin D and thyroid profile assessment.