Comparative study of esomeprazole and omeprozole on human by serum pepsinogen-I estimation method as a bio marker of gastric inflammation

Abstract

Background: Proton pump inhibitors are widely used for gastroesophageal disorders. The present work was carried out ot compare effect of omeprazole & esomeprozole for gastric ulcer healing. Methods: pepsinozen-I (none- Invasive) estimation method was taken. The Peasants were divided into control groupo, omeprazole group and esomeprozole group. and effect of two drugs with regard to pepsinozen-I compared with control and with each other. Analysis of variance oand Student's t-tests, and ANOVA were applied to compare the results. Results: It was found that the mean pepsinozen-I level varied significantly across the three groups (p=.000). Compared to the control group, the pepsinozen-I level was significantly less in both omeprazole and esomeprozole groups (p=.000). But the pepsinozen-I level was significantly less in esomeprozole in comparison to omeprazole(p=.001). It was evident that esomeprozole was more eficapious than omeprazole as far as acid reflux disorder was concerned .