Study of dyslipidemia associated with chronic kidney disease

Abstract

Background: Chronic Kidney Disease (CKD) hasan increased risk of cardiovascular diseases (CVD) prevalence and lethality. Dyslipidemia is mostly associated in these patient populations with abnormalities in lipid profile and is a principal risk factor for CVD development. Patients with CKD exhibithigh triglycerides, low high density lipoprotein-cholesterol,and altered lipoprotein composition. Aims and objectives: The study was undertaken to observe the lipid profile of healthy and diseased subjects to study its association with CKD. Material and Methods: A total of 100 subjects were included; of which 50 were the control group and 50 were thestudy (evidence of CKD) group. 5ml of venous blood was obtained from antecubital fossa from each subject and kept in a plain vial, after which serum separation was analyzed for biochemical parameters. Results: Among various parameters tested urea, creatinine, sugar, triglycerides, and very low-density lipoprotein levels were significantly higher in the study group as compared to the control group (p<0.05). Low-density and high-density lipoprotein levels were significantly lower in the study group as compared to the control group (p<0.05). There was no significant change observed in total lipids and phospholipids levels in between the healthy control and studygroup. Conclusion: It can be concluded that CKD patients are at higher risk of development of hypertriglyceridemia, dyslipidemia characterized with elevated urea and creatinine, and decreased HDL levels leading to more prevalence of CVD.