A Study On Risk Factors of Relapses of Nephrotic Syndrome Among Pediatric Patients at a Tertiary Care Center of Bihar
Keywords:Risk Factors, Relapses, Nephrotic Syndrome
Introduction: Nephrotic syndrome (NS) is 15 times more common in children than in adults. NS affects13/100,000 children<16 years of age . Two-thirds of childhood NS present before the age of 6 years. Therefore, we planned this study with an objective to identify the risk factors for FR in childhood steroid sensitive NS (SSNS). Methodology: A prospective study was conducted by the Department of Pediatrics, Nalanda Medical College &Hospital, Bihar, between February 2020 to January 2021. Cases with the first episode of idiopathic SSNS in the age group of 9 months - 12 years, who followed up for at least 12 months were enrolled in the study. NS was diagnosed in accordance with standard criteria. Results: A total of 100 children with NS were included in the current study based on inclusion criteria during the study period. There was a male preponderance among the study participants. Incidence of infection and hypertension was 34% and 37%, respectively. Incidence of FR was high in 1-8 years age group. The incidence of FR was less in males than in females; but it was not significant. Majority of the children with IFR group responded to steroid therapy in <2 weeks, while the most children with FR showed response after 3-4 weeks. Conclusion: Relapse within first 6 months, associated infections and hypertension were the factors significantly associated with FRs in childhood SSNS. These factors should be kept in mind and should be well documented at the time of initial presentation of NS for the long-term management.
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Copyright (c) 2022 Ramjee Prasad Gupta, Ranjit Kumar, Sneha Jaiswal, Binod Kumar Singh, Akhilesh Kumar
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