A descriptive study of effect of blood donation on lipid profile in healthy volunteers
Keywords:Blood donation, TC, LDL, VLDL, HDL, Hypertension, Diabetes Mellitus.
Introduction: Blood donation is a process by which a blood donor voluntarily has drawn the blood for the shortage in the blood bank or for subsequent use in blood transfusion. There is considerable shortage of blood even in large metropolitan cities with supply being less than 50% than the requirement. Materials and methods: This is descriptive study. Blood donation camp was organized in RIMS, Ranchi. 60 healthy males who were willing to participate were selected for the study. The Inclusion criteria being age between 18 years and 25 years, weight between 50 kg and 60 kg and haemoglobin levels should be > 10 mg %. Exclusion criteria are volunteers having history suggestive of chronic illnesses like Hypertension, Diabetes Mellitus, Hepatitis B, Haemoglobinopathies, Bleeding disorders, Alcoholics, Chronic smokers, Drug abuser, H/O blood donation within last one month. The samples of 60 healthy volunteers were collected in fasting condition. With all aseptic condition, 5 ml venous blood was withdrawn and centrifuged. Separated serum was used for further analysis. Results: All the parameters of lipid profile, e.g. TC, LDL, VLDL except HDL was highly significantly decreased (p<0.001) after 7th and the effects continued till 30th day after blood donation, which was highly significantly decreased (p<0.05, HDL). It was significantly increased (p <0.05) after 7th and 30th day of blood donation. At 90th day, all values were normalised. Conclusion: Blood donation has lipid lowering effects as early as 7 days after blood donation and effects were maintained till 30th day after blood donation. During this period, i.e. on day 7 and 30, there was significant decrease in TC, LDL, TG and VLDL levels with significant elevation of HDL concentration. The lipid profile returns to normal after 90 days of blood donation in healthy volunteers.
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Copyright (c) 2022 Pradeep Prasad, Mukesh Kumar Niraj, Riya Kumari
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