Comparative evaluation of hemodynamic changes after different doses of cisatracurium and atracurium

Abstract

Background and aims: Neuromuscular blockers have become essential part of anaesthesiologist armamentarium. They aid endotracheal intubation, mechanical ventilation, reduce anaesthetic requirement, prevent patient movement and facilitate surgery. The ideal neuromuscular relaxant is an agent which has a quick onset time and short duration of action. We compare the efficacy of Atracurium besylate and different doses of Cisatracurium besylate for hemodynamic response during intubation and histamine response. Material and methods: Randomized trial was conducted in ninety patients of ASA grade I and II ,posted for elective abdominal surgeries were randomly allocated into three groups, of 30 patients each, depending on muscle relaxant and its doses used for intubation . Results: In our study, we found that cisatracurium with the dose of 0.2 mg/kg B.W. is better hemodynamic stable agent and lesser histamine response than cisatracurium 0.1mg/kg B.W. and atracurium 0.5 mg/kg B.W. Conclusion: Cisatracurium is lack of histamine release even at larger doses, which provides better hemodynamic stability in comparison to atracurium and other histamine releasing neuromuscular blocking agents.