A cross sectional study of expression of CK-19 in papillary thyroid carcinoma and its association with prognostic factors
Keywords:Thyroid malignancies, Papillary carcinoma, multinodular swelling, Cytokeratin 19.
Introduction: Thyroid malignancies are the most common endocrine malignancy. The most common malignancy in thyroid is papillary thyroid carcinoma. About 80% of all thyroid cancers are papillary carcinoma thyroid. Papillary carcinoma typically arises as an irregular, solid or cystic mass that comes from otherwise normal thyroid tissue. Papillary carcinoma has a high cure rate with 10-year survival rates for all patients with papillary carcinoma thyroid estimated at 80% to 90%. Materials and Methods: The study was undertaken in the Department of Pathology, Jangaon district hospital, Jangaon. The study was conducted from January 2020 to December 2020. A total of 46 cases including 29 cases of papillary carcinoma thyroid, 17 cases of papillary hyperplasia. Papillary carcinoma and its variants, Beningn lesions with papillary hyperplasia was included. Other malignancy including follicular carcinoma, medullary carcinoma without papillary areas, Benign lesions without papillary hyperplasia were excluded from the study. Results: In this study most of the papillary carcinoma of thyroid occur in the age group between 20-50 years. Most of the cases were diagnosed mostly 3 rd to 5th decades. In males, out of 29 cases 5 cases were males, mostly occur above 40 years. The mean age group is 43.9 years. In this study most of the papillary lesions arises from solitary nodular swelling, in our study out of 29 cases of papillary carcinoma 19 cases arises from solitary nodular swelling,5 cases from multinodular swelling , 5 cases from diffuse thyroid lesion. Conclusion: In our study most of all papillary carcinoma and its variants shows diffuse and strong positivity against anti ck 19 antibody. Papillary hyperplasia shows negative stain except 2 cases. We conclude diffuse and strong positivity confirms that the diagnosis of papillary carcinoma thyroid. Negative stain indicates it is a benign lesion. Cytokeratin 19 is a useful marker to differntiate papillary carcinoma from other benign lesions shows papillary hyperplasia.
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