Hemodynamics and Pain on injection, A comparison observational study between Propofol MCT_LCT and Propofol LCT preparations

Authors

  • Dhivya Marium Jacob Assistant Professor, KMCT Medical College, Calicut, Kerala, India
  • Jomy P Thomas Assistant Professor, KMCT Medical College, Calicut, Kerala, India
  • Mary Albert D Professor, Pushpagiri Institute of Medical Sciences And Research Center, Thiruvalla, Kerala, India

Keywords:

Propofol Medium Chain Triglyceride / Long Chain Triglyceride, Propofol Long Chain Triglyceride, Lipid Emulsion, Four point scale.

Abstract

Introduction- Propofol is an intravenous induction agent popular for induction, maintanence and smooth recovery from anaesthesia in both adults and children. It has gained popularity due to its intravenous sedative – hypnotic property producing rapid unconsciousness. The conventional preparation of Propofol contains a higher percentage of aqueous phase which contains free propofol responsible for pain on injection. Objectives – To compare the injection pain on induction with 1% Propofol LCT and 1% Propofol MCT / LCT preparations. To compare intraoperative hemodynamic changes between the two preparations. Methods- The current study is an observational study done in Fifty patients aged 20-60 years of American Society of Anaesthesiologists (ASA) Physical status I and II undergoing surgery under General Anaesthesia in Pushpagiri Institute of Medical Science and Research Centre. Patients were recruited by consecutive sampling technique, grouped into two with each group having 25 each. Group MCT – received Propofol MCT / LCT (2mg/kg), Group LCT – received Propofol LCT (2mg/kg). The pain was assessed by a second anaesthesiologist using the 4 point scale. Results - The incidence of pain was more with Group LCT. The incidence of pain score 0 with no pain were 0% in Group LCT whereas 16% in Group MCT. The incidence of pain score 1 was highest in Group MCT with 76% whereas 4% with Group LCT. The incidence of pain score 2 was highest in Group LCT with 60% vs 8% in Group MCT. Conclusion- Propofol Medium Chain triglyceride / Long Chain triglyceride used for intravenous injection did not eliminate pain completely but definitively had less pain on injection compared to Propofol Long Chain Triglyceride preparation. There were no significant hemodynamic changes for both the groups other than heart rate variability.

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Published

2022-01-17

How to Cite

Dhivya Marium Jacob, Jomy P Thomas, & Mary Albert D. (2022). Hemodynamics and Pain on injection, A comparison observational study between Propofol MCT_LCT and Propofol LCT preparations. International Journal of Health and Clinical Research, 5(2), 459–461. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/4252