Evaluation of clinical profile of febrile thrombocytopenia

Authors

  • Latha V Resident, Department of Medicine, VIMS, Ballari, Karnataka, India
  • Shashibhushan J Professor, Department of Medicine, VIMS, Ballari, Karnataka, India
  • Shruthi J Resident, Department of Medicine, VIMS, Ballari, Karnataka, India

Keywords:

Dengue, thrombocytopenia, spontaneous bleeding, febrile illness

Abstract

Background: Fever is the most common presenting symptoms. An A.M temperature of >37.2°C (98.9°F) or a P.M temperature of >37.7°C (99.9°F) will be considered as fever. Thrombocytopenia is defined as platelet count <150,000/μl. This is due to decreased production of platelets, increased destruction and increased sequestration in the spleen. Study aimed to evaluate clinical profile, infective etiology for fever with thrombocytopenia and to study the presentation and complications of thrombocytopenia. Method: The prospective study was conducted in patients admitted in medical college hospitals affiliated to Vijayanagar Institute of Medical Sciences, Ballari, period of 2 years from November 2017 to October 2018. Patients presenting with fever with thrombocytopenia were taken up for study. Age and gender distribution, duration of fever, clinical features, platelet counts, bleeding manifestations, liver function tests and presence of various etiologies was studied. Results: A total of 120 patients were studied. The patient age ranged from 18 years to 70 years and the mean age was 35.38 years (SD=14.19) and the male (n=72) patients were more than female(n=48) patients. The diseases which contributed mainly to febrile thrombocytopenia in our study were Dengue (40%), Malaria (24%), Leptospirosis (8%) and septicemia (10%) and other causes (18%) acute viral fever. The duration of fever ranged from 1-15 days with mean duration of 6.05 days and 92% of them had duration of < 10 days. Headache was the most common symptom other than fever in the present study. Derangement of LFT was also observed in most of the cases. Spontaneous bleeding were seen 42 number of patients. In our study 112 patients recovered and 6 expired. Conclusion: Fever with thrombocytopenia consists of occult presentations of common diseases rather than rare disease. Febrile illness patients should be investigated for platelet count irrespective of bleeding manifestations. Infection is the commonest cause of fever with thrombocytopenia. Among infections, dengue and malaria were the commonest cause. Fever and thrombocytopenia as decreased platelet count could indicate the severity of disease without external manifestation and could be an indicator of bad prognosis and treatment of underlying condition will lead to rapid improvement in platelet count with complete clinical recovery.

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Published

2022-01-17

How to Cite

Latha V, Shashibhushan J, & Shruthi J. (2022). Evaluation of clinical profile of febrile thrombocytopenia. International Journal of Health and Clinical Research, 5(2), 465–467. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/4254