Comparative study of oxidative stress and antioxidant status between ischemic and haemorrhagic stroke patients
Introduction: The World health organization (WHO) has defined stroke as “rapidly developed clinical signs of focal and at times global disturbances of cerebral function lasting more than 24 hours or leading to death, with no apparent cause other than vascular origin.” Stroke is an interruption in the cerebral vasculature and is classified as being either ischemic stroke (IS) or haemorrhagic stroke (HS). Material and Methods: This is a Prospective, observational and Case Control study conducted in the Department of Biochemistry and Casualty Unit at Mahavir Institute of Medical Sciences over a period of 1 year on an overall population of 140 individuals (40 ischemic strokes and 30 haemorrhagic strokes as the case groups; 70 healthy individuals as the control group). The diagnosis of stroke was based on history and clinical examination and brain CT scan were used to confirm and classify ischemic and haemorrhagic stroke cases. Results: In our study, we observed that mean serum levels of Malondialdehyde (MDA) were increased in both ischemic 2.96 ± 0.51 nmol/mL and hemorrhagic stroke 2.41 ± 0.42 nmol/mL as compared to controls 1.38 ± 0.26 nmol/mL. We found reduced mean level of serum Superoxide dismutase (SOD) in cases of ischemic (9.41 ±2.52 U/mg) and hemorrhagic stroke (8.86±2.73 U/mg) as compared to controls (15.51 ±3.62 U/mg). The Catalase levels are decreased significantly in ISPs and HSPs compared to control subjects. Maximum decline in Catalase is found in ISPs with HSPs. Conclusion: Result showed a direct positive correlation with infarct size (Ischemic stroke) but less in hemorrhagic stroke when comparted with control group. The antioxidative parameters like Catalase and superoxide dismutase was decreased both ischemic and hemorrhagic stroke when compared with control.
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Copyright (c) 2022 Amtul Rahman Amberina, Zehratul Quresh, Ravirala Tagore, Ayesha Jabeen
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