A Comparative Study of Two Different Doses of Dexmedetomidine on Attenuation of Stress Response to Endotracheal Intubation in Patients Undergoing Elective Surgeries Under General Anaesthesia

Authors

  • Sanmugapiriya K Associate Professor, Department of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, India
  • Vigneswaran. J Assistant Professor, Department of Anaesthesiology, Sri Manakula Vinayagar Medical College, Pondicherry, India
  • Lavanya. E Assistant Professor, Department of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, India
  • Vishwanath R Hiremath Professor, Department of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, India

Keywords:

Dexmedetomidine, Laryngoscopy, Tracheal intubation, Stress response.

Abstract

Introduction: Under general anaesthesia, laryngoscopy and endotracheal intubation elicit a strong sympathoadrenal response with potentially fatal implications in individuals with cardiovascular and cerebrovascular illnesses. To counteract this reaction, a variety of pharmacological treatments have been used.Aim: The present study was planned to compare the effects of two different doses of dexmedetomidine (bolus doses) on attenuation of stress response to Laryngoscopy and Endotracheal Intubation. Materials & Methods: A Randomized double-blinded prospective comparative study. Sixty patients of both sex (ASA grade I or II) undergoing GA were randomly divided into two groups equally as Group A (dexmedetomidine 1μg·kg− 1) and Group B (dexmedetomidine 0.5μg.kg− 1). Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded at baseline, after completion of infusion (T1), 1 min (T2), 3min (T3), 5min (T4), & 10min (T5) following intubation.Results: The Student’s independent t-test was employed for comparing continuous variables. Chi-square test or Fisher’s exact test, whichever is appropriate, was applied for comparing categorical variables. Immediately after intubation, there was a lesser rise of SBP, DBP, and MAP in both the groups but there was a significant reduction in pressure values in group A at 1 minute after intubation compared to group B. Conclusion: Dexmedetomidine at a dose of 1μg·kg-1administered over 10 minutes before induction of general anaesthesia more effectively attenuates the haemodynamic response to laryngoscopy and intubation than dexmedetomidine 0.5μg·kg-1infusion over the same period, without any significant adverse effects.

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Published

2022-01-16

How to Cite

Sanmugapiriya K, Vigneswaran. J, Lavanya. E, & Vishwanath R Hiremath. (2022). A Comparative Study of Two Different Doses of Dexmedetomidine on Attenuation of Stress Response to Endotracheal Intubation in Patients Undergoing Elective Surgeries Under General Anaesthesia. International Journal of Health and Clinical Research, 5(1), 456–460. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/4540