Correlation of primary tumor FDG uptake with clinicopathologic prognostic factors in invasive ductal carcinoma of the breast

Authors

  • Peethamber Lokanandi Consultant, Department of Nuclear Medicine and PET CT, Mahatma Gandhi Cancer Hospital and Research Institute, Vishakhapatnam, Andhra Pradesh, India
  • Mohd Abdul Rawoof Registrar, Department of Radio Diagnosis, Apollo Hospitals, Jubilee hills, Hyderabad, Telangana, India
  • Karanam Poorna Sasank Registrar, Department of Radio Diagnosis, Apollo Hospitals, Jubilee hills, Hyderabad, Telangana, India
  • Esparanto Sudanagunta Registrar, Department of Radio Diagnosis, Apollo Hospitals, Jubilee hills, Hyderabad, Telangana, India
  • Chandra Rakesh Chowdary Department of Radio Diagnosis, Apollo Hospitals, Jubilee hills, Hyderabad, Telangana, India

Keywords:

PET CT, SUVmax, ER, PR

Abstract

Introduction: 18F-fluoro-2-deoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) has become an important tool in the evaluation of patients with invasive breast cancer by revealing the functional properties of breast tumors[1]. The maximum standardized uptake value (SUVmax) measured with FDG PET is a sensitive indicator for metabolic activity in breast cancer[2-10], which can be used to assess tumor aggressiveness and is associated with prognostic factors, such as the histological type, histological grade, immunohistochemical factors, and proliferation index[11,2-10]. PET with F-18 FDG has been widely used in clinical practice for the diagnosis, staging, treatment monitoring, and detection of disease recurrence in breast cancer patients[12]. Aim/purpose: To correlate clinicopathologic variables (tumor size, histologic grade, TNM stage, status of the hormonal receptor (ER, PR, HER2 expression) with PET-CT parameters such as maximum standardized uptake value(SUVmax). Materials and methods: This was a hospital based prospective cross sectional analytical study conducted for 19 months at Apollo Hospitals, Hyderabad. In the total of 70 participants after explanation of the procedure study and taking written informed consent who were diagnosed with invasive ductal carcinoma of the breast during the study period undergoing FDG PET CT scan, 55 participants were included for the study in accordance to inclusion and exclusion criteria. 15 participants were excluded. Patient was assessed for age, menopause status, tumor size (T), tumor grade (G), hormone receptor status (ER, PR, Herer2neu) and stage. Patient undergoes FDG PET CT for diagnostic evaluation. Measurement and assessment of FDG pSUVmax (mean + S.D.) in primary tumor of ductal carcinoma of the breast and correlation with clinicopathologic variables was done. Results: SUVmax was higher in the participants with higher tumor stage andhighertumorgrade.TheSUVmaxvaluesforT4stage, pTNMstageIVandGrade3 tumors were respectively 20.4 ± 2.0; 17.1 ± 3.5; and 13.2 ± 3.2. SUV max was also higher i nparticipants who were ER and PR negative(13.2±3.0; ±5.4), premenopausal women, patients with higher tumor stage, higher histological grade - poorly differentiated tumors, ER and PR negativity, triple negative receptor status and positive axillary lymph node status. Conclusion: The study demonstrates that SUVmax values are related to the recognized histopathologic and immuno histochemical prognostic factors in breast cancer predictability of predictive and prognostic factors before treatment is of importance in terms of deciding the therapeutic approach. In preoperative assessment of patients with breast cancer, PET/CT scanning is inadequate in examining axillary lymph nodes; however,it may prove beneficial in displaying the biologic characteristics and behavior of a tumor.

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Published

2022-01-17

How to Cite

Peethamber Lokanandi, Mohd Abdul Rawoof, Karanam Poorna Sasank, Esparanto Sudanagunta, & Chandra Rakesh Chowdary. (2022). Correlation of primary tumor FDG uptake with clinicopathologic prognostic factors in invasive ductal carcinoma of the breast. International Journal of Health and Clinical Research, 5(2), 675–687. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/4784