COMPARISON OF COMBINED ORAL CONTRACEPTIVES AND CYPEROTERONE ACETATE-ETHINYL ESTRADIOL COMBINATION ON CLINICAL AND HAEMATOLOGICAL PARAMETERS IN POLYCYSTIC OVARIAN SYNDROME (PCOS)

Abstract

Introduction: Polycystic ovarian syndrome (PCOS) is an endocrine disorder with multiple etiology and affecting women in reproductive age group. It has become a major problem in modern era and requires a multimodality of treatment. Material and Methods: The study was conducted on 100 PCOS patients attending PGIMS, Rohtak outpatient department to compare the efficacy of combined oral contraceptives (COCs) and cyperoterone acetate-ethinyl estradiol (CPA-EE) combination on clinical and hematological parameters. This was a prospective interventional study conducted for one and half year. Patients were followed at one, three and six months of treatment and comparison was made from baseline to six months of treatment. Results: Both the drugs showed improvement in acne and hirsutism while no effect was seen on acanthosis nigricans, and anthropological parameters (basal metabolic rate, waist circumference, and waist hip ratio). Serum testosterone levels and sonographical parameters (ovarian volume, necklace appearance) also improved. On the contrary both the drugs deteriorated blood sugar levels and lipid profile of the patients on successive follow ups. However on comparison COCs deteriorated blood sugar levels more as compared to CPA-EE and CPA-EE deteriorated lipid profile (triglyceride and cholesterol levels) more than COCs. CPA-EE also improved the serum testosterone levels more when compared to COCs. Conclusion: Any of the drugs can be used in the treatment of PCOS patients but with caution in diabetic and hyperlipidemic patients.