Etiology of Pyrexia of Unknown Origin on Bone Marrow Examination- In a tertiary care centre

Authors

  • Avinash Priyadarshi Assistant Professor, Department of Pathology, MGM Medical College, Kishanganj, Bihar, India
  • Ankur Priyadarshi Assistant Professor, Department of Paediatrics, Jawaharlal Nehru Medical College Bhagalpur, Bihar, India
  • Rishav Kumar Singh Tutor, College, Department of Pathology, MGM Medical Kishanganj, Bihar, India
  • Harpreet Kaur Tutor, College, Department of Pathology, MGM Medical Kishanganj, Bihar, India
  • Amitabh Anand Tutor, College, Department of Pathology, MGM Medical Kishanganj, Bihar, India

Keywords:

Pyrexia of Unknown Origin, Bone Marrow Examination, Malignancy, Acute myeloid leukemia

Abstract

Background: Pyrexia of unknown origin (PUO) has been defined by Petersdorf and Beeson as patient complaint of increased body temperature of more than 38.30C developing over a period of a ≥ 3 week before specific diagnosis including 1 week of investigation in hospital. In the present study, an attempt has was made to find out the causes of PUO based on bone marrow morphological finiding. Bone marrow examination plays an important role in early diagnosis of core cause for PUO and is the best investigating tool for haematological and non-haematological disorders in any age group. Materials & Method: It was a prospective study conducted in Department of Pathology, MGM Medical college & LSK hospital, Kishanganj, during the period of September 2019 to august 2021. All patients presenting with classical PUO whether inpatient or outpatient coming to Medical College fulfilling the criteria of Petersdorf RG et al. Results: Out of 56 patients, 35 were males and 21 were females. Age of patients varied from 2 years to 70 years. Majority of patients were in the age group of 30-44 years comprising of 32.2% of total cases. Most common diagnosis was neoplastic changes, seen in 30.3% of patients, reactive myeloid hyperplasia was seen in 21.4% cases,14.2% cases show megaloblastic anemia, iron deficiency was seen 3.6 % cases, haemophagocytosis in 5.3% cases, 5.3% cases showed hypocellular marrow. Among infections, malaria was the commonest constituting 5.3% cases. Out of total of 17 cases of neoplastic changes in bone marrow, majority of them were acute myeloid leukaemia seen in 35.3% cases. Conclusions: Bone marrow examination is most important investigation of PUO in arriving at an etiological diagnosis. The most common causes of pyrexia of unknown origin observed in children were acute lymphoblastic leukaemia, and haemophagocytosis, whereas in adults, the main causes were malignancies, reactive myeloid hyperplasia and megaloblastic anaemia . This study reflect light on the current spectrum of diseases causing pyrexia of unknown origin in this region.

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Published

2022-01-17

How to Cite

Avinash Priyadarshi, Ankur Priyadarshi, Rishav Kumar Singh, Harpreet Kaur, & Amitabh Anand. (2022). Etiology of Pyrexia of Unknown Origin on Bone Marrow Examination- In a tertiary care centre. International Journal of Health and Clinical Research, 5(2), 982–984. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/5059