Comparison between oral clonidine and oral pregabalin as premedication to attenuate pressor response to direct laryngoscopy and endotracheal intubation

Authors

  • Dubagunta Naga Likhitha Postgraduate, Department of Anaesthesiology, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, West Godavari District, Andhra Pradesh, India
  • Nayan Sriramula Post Graduate, Department of Emergency Medicine, Narayana Medical College Hospital, Nellore, Andhra Pradesh, India
  • R. Rajeshwar Reddy Assistant Professor, Department of Anaesthesiology, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, West Godavari District, Andhra Pradesh, India
  • K.S.S.G.C.Kumar Professor, Department of Anaesthesiology, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, West Godavari District, Andhra Pradesh, India

Keywords:

Clonidine, Pregabalin, direct laryngoscopy, endotracheal intubation.

Abstract

Background: Laryngoscopy and endotracheal intubation are the modern routine procedures of balanced general anaesthetic technique. Laryngoscopy and tracheal intubation induced pressor responses have been associated with increased catecholamine levels. So, it is important to find an effective means by attenuating the sympathetic response to laryngoscopy and intubation. Pregabalin decreases pre-operative stress and anxiety response to intubation. Premedication with Clonidine is to produce sedation and blunt the stress response to intubation. Aim: To compare the efficacy of Oral CLONIDINE with Oral PREGABALIN as premedication to attenuate pressor response to direct laryngoscopy and endotracheal intubation. Materials and methods: This was a prospective study, approved by the institutional ethical committee. A total of 60 patients undergoing elective surgery were selected A total of 60 patients were divided into two groups of 30 each, group C (clonidine), and groupP (pregabalin). careful preanesthetic evaluation should be done for all the patients. A valid informed consent should be obtained both for conduct of study as well as for surgery and anaesthesia. Patients should be kept nil per oral from midnight before surgery. Discussion: Induction of general Anaesthesia, direct laryngoscopy and endotracheal intubation attenuates marked cardiovascular changes and also the activity of autonomic reflex. The response may be particularly haphazard to the patients with cardiovascular and cerebral diseases. Most of the studies have reported the use of oral Clonidine premedication to prevent hyper-adrenergic and dynamic cardiovascular responses to endotracheal intubation have been successful. Pregabalin had been shown to be effective in neuropathic pain, diabetic neuropathy, acute post-operative pain and decreasing the postoperative opioid requirements. Conclusion: Clonidine was found to be more effective than Pregabalin in lowering of blood pressure and heart rate changes associated with laryngoscopy and intubation. Pregabalin when compared with Clonidine gives better postoperative analgesia, more sedation and less bradycardia.

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Published

2022-01-16

How to Cite

Dubagunta Naga Likhitha, Nayan Sriramula, R. Rajeshwar Reddy, & K.S.S.G.C.Kumar. (2022). Comparison between oral clonidine and oral pregabalin as premedication to attenuate pressor response to direct laryngoscopy and endotracheal intubation. International Journal of Health and Clinical Research, 5(1), 680–683. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/5137