To Determine Serum Ferritin and Lipid Profile in Type 2 Diabetes Mellitus
Keywords:Diabetes mellitus, Glycated haemoglobin, fasting blood glucose, serum ferritin, lipid profile.
Background: Type 2 diabetes mellitus is a major growing health concern worldwide. In recent years much is talked about the role of serum ferritin, a marker of iron stores in the body in the development of type 2 diabetes mellitus and its complications. This study was carried out to assess the levels of serum ferritin in type 2 diabetes mellitus and to find its correlation with glycaemic control. Method: Total 188 subjects were enrolled in the study, including 94 clinically diagnosed patients of type 2 Diabetes Mellitus in the age group of 35-60 years and 94 normal age and sex matched non diabetic control. All subjects were clinically examined, had laboratory investigations including fasting and 2 hour post prandial blood glucose, HBA1c%, serum ferritin and lipid profile. Statistical analysis was carried by using student’s ‘t’ test and Pearson’s correlation coefficient (r) was used to assess correlation between measured parameters. Results: The study showed that serum ferritin levels were significantly increased in diagnosed cases of type 2 diabetes mellitus as compared to age and gender matched healthy control (P = < 0.01). A strong positive correlation was observed between serum ferritin and HBA1c % (r= 0.78, P= <0.01). Serum total cholesterol, triglycerides, LDL-C and VLDL-C was significantly increased in cases as compared to control while serum HDL-C was significantly decreased in cases as compared to control. (P= <0.01) Significant positive correlation was observed between serum ferritin and parameters of lipid profile. Conclusion:The study showed increase serum ferritin levels and dyslipidaemia in diagnosed cases of diabetes mellitus as compared to healthy control which suggest that increase iron may contribute to pathogenesis and complications of diabetes mellitus. Our results provide evidence that serum ferritin levels are significantly associated with major lipid parameters and this association represents a cardiometabolic risk factor.
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Copyright (c) 2022 Shilpa Sunil Shende, Vishakha Vivek Mahajan, Arun Tadas, Mangesh Tekade
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