A Study of Association Between Serum Paroxanase Enzyme Activity with Dyslipidaemia in Obese Individuals

Abstract

Introduction: Obesity, defined as the excessive accumulation of body fat, is frequently associated with a low concentration, adverse distribution pattern, and abnormal metabolism of HDL particles. Obesity is a highly prevalent chronic state observed in 32% of all adults in the United States. Material and Methods: This is prospective study conducted over a period of 6 months among Obese participants were selected at Tertiary care teaching hospital and had never been diagnosed with T2D or prediabetes, as evidenced by an HbA1c of less than 5.5 percent. Healthy volunteers from made up the control group. History of cancer, prior chemotherapy or radiotherapy, diabetes, prediabetes, anaemia, hereditary neuropathies, inborn inconsistencies of metabolism, undiagnosed vitamin/mineral deficiencies, low vitamin B12 or folate tiers that may impact the cornea were all considered exclusion criteria. The Ethics Committee gave their approval to this project. Results: We studied 30 participants with severe obesity compared to 30 age-matched healthy controls (P=0.5). The obese group had a significantly higher weight (P<0.0001), waist circumference (P<0.0001) and BMI (P<0.0001), but no statistically significant difference in HbA1c, blood pressure compared to controls. Conclusion: Patients with obesity had elevated serum triglycerides and SAA and lower HDL-C, PON-1 activity. Furthermore, obese subjects had higher serum triglycerides and prevalence of metabolic syndrome and lower PON1 activity.