Correlation between Glycosylated Haemoglobin and Dyslipidaemia in Patients with Type 2 Diabetes Mellitus

Authors

  • Amena Tasneem Assistant Professor, Department of Biochemistry, Shadan Institute of Medical Sciences, Hyderabad, Telangana, India
  • Helena Vemuri Assistant Professor, Department of Biochemistry, Shadan Institute of Medical Sciences, Hyderabad, Telangana, India
  • Mohammad Ibrahim Shaik Associate Professor, Department of Biochemistry, Shadan Institute of Medical Sciences, Hyderabad, Telangana, India
  • Mohammed Siddique Ahmed Khan Prof and HOD, Department Of Biochemistry, Shadan Institute of Medical Sciences, Hyderabad, Telangana, India

Keywords:

Type 2 diabetes, Glycosylated haemoglobin, Dyslipidaemia.

Abstract

Introduction: Diabetic patients with concomitant dyslipidemia are often soft targets for cardiovascular disease and deaths. An early intervention to normalize circulating lipids has been shown to reduce cardiovascular morbidity and mortality. Hence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients. Material and Methods: This was a cross-sectional and prospective study was carried out at Tertiary Care Teaching Hospital over a period of 6 months of 70 T2DM patients with dyslipidaemia who had visited the hospital. Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and glycated haemoglobin (HbA1c) levels were evaluated. Test of significance was calculated by unpaired Student’s’t’ test. Correlation studies (Pearson's correlation) were performed between glycated haemoglobin (HbA1c) and serum lipid profile. Results: Distribution of Glucose Triad results of FBS, PPBS and HbA1c levels of patients presented as Mean± SD, mean FBS was 173.59±39.64, mean PPBS was CBYU 234.59±94.59 and mean HbA1c was 7.78±0.83. Mean total cholesterol was 226.53 ± 19.53, mean total triglyceride was 213.83 ± 20.65, Mean HDL was 35.63 ± 3.96, mean LDL was 148.14 ± 7.63 and VLDL was 42.76 ± 3.69. HbA1c positively and significantly correlated with total cholesterol (r=0.213), LDL (r=0.304), HbA1c negatively and significantly correlated with HDL (r= - - 0.128), and did not show any show correlation with VLDL (r=0.049) and total triglycerides (r=0.049). Conclusion: The study indicates the usefulness of HbA1c as a marker for lipid profile for screening of diabetic patients at high risk of developing cardiovascular diseases.

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Published

2021-12-31

How to Cite

Amena Tasneem, Helena Vemuri, Mohammad Ibrahim Shaik, & Mohammed Siddique Ahmed Khan. (2021). Correlation between Glycosylated Haemoglobin and Dyslipidaemia in Patients with Type 2 Diabetes Mellitus. International Journal of Health and Clinical Research, 4(24), 1–3. Retrieved from https://www.ijhcr.com/index.php/ijhcr/article/view/3735