Effects of Intravenously Administered Dexmedetomidine and Clonidine on Haemodynamic Response and Post Operative Analgesia in Laparoscopic Surgery: An Observational Study

Abstract

Introduction: Laparoscopic surgery is become the normal now due to its advantages. To counter its disadvantages on haemodynamics, α-2 receptor agonists clonidine and dexmedetomidine are increasingly being used during laparoscopic procedures. Aim: To compare the haemodynamic response, perioperative analgesia, and sedative effects of intravenous dexmedetomidine versus intravenous clonidine given as premedication among patients receiving general anaesthesia for elective laparoscopic surgeries. Materials and methods: The study was an observational, prospective, comparative study in which Group D was given Injection dexmedetomidine 1 μ/kg in 100 ml of normal saline intravenously and Group C was given Injection clonidine 2μ/kg in 100ml of normal saline intravenously before induction of general anaesthesia. Results: Data was calculated as mean, median, and standard deviation. Any statistical difference between the two proportions was estimated using the Chi-square test and any statistical difference between had better hemodynamic control and post-operative analgesia. Both dexmedetomidine and clonidine attenuated the cardiovascular and pressor response to intubation. Dexmedetomidine caused deeper sedation and better analgesia in comparison to clonidine. Conclusion: Alpha 2 agonist dexmedetomidine and clonidine provide haemodynamic stability among patients undergoing laparoscopic surgery. Dexmedetomidine provided much better cardiovascular stability and superior analgesia.