Demographic characterization, risk factors and antimicrobial susceptibility pattern of UPEC associated UTI

Abstract

Objective: To determine the demographic characterization of patient with urinary tract infection and antimicrobial susceptibility pattern of UPEC in our region. Methods: This study was a cross sectional analytical study done for period of one year. All the patients suspected or diagnosed with UTI,their urine specimen were send for culture and sensitivity. Results: Catheterization (27.27%) is the most common risk factor followed by bladder outlet obstruction due to BPH. The highest antibiotic resistance was observed for all isolates with Ampicillin (96 %) followed by Amoxyclav (80%) and highest sensitivity was found with Cotrimoxazole (85%) and Nitrofurantoin (85%) among oral antibiotics. Ceftriaxone (80 %) and Cefotaxim (75%) were found to be highly resistant among parenteral antibiotics whereas highest sensitivity of the isolates was observed with Imipenem (98 %) followed by Piperacillin + Tazobactum (95 %) and Amikacin (85 %). Imepenam was found to be 100 % sensitive in UPEC isolated from uncomplicated UTI whereas only 1 isolate was resistant to Piperacillin + Tazobactum. Conclusion: In the present study, highest percentage of resistance was observed with Ampicillin (96%) followed by Amoxicillin + clavulanate (80%) Ceftriaxone (80%) and Gentamycin (75%). Antibiotic sensitivity pattern varies according to the pathogens associated with the disease and also depend on the antibiotic policies in that region.In most of the places especially in rural areas where culture facilities are not available ampicillin, amoxicillin + clavulinic acid and fluroquinolones are frequently prescribed as a oral agents and Ceftriaxone and Aminoglycosides as a parenteral treatment leads to development of resistant strains.