Therapeutic effects of 5 flourouracil in combination with crystalline triamcinolone acetonide suspension in treatment of keloids

Abstract

Background: Keloids are benign hyperproliferations of dermal connective tissue. Injury of the deep dermis commonly results in scar formation. The present study was conducted to assessed therapeutic effects of 5 flourouracil in combination with crystalline triamcinolone acetonide suspension in treatment of keloids. Materials & Methods: 72 patients with keloids of both genders were treated with cryotherapy (spray cryotherapy using liquid nitrogen twice for 10 s; cryotherapy was usually performed 15–30 min before the injection of TAC) and TAC every 4 weeks at least three times without significant improvement. Results: Out of 72 patients, males were 40 and females were 32. Common site was chest in 20, shoulder in 12, back in 8 and all sites in 32. Previous therapy was TAP in 10, cryotherapy in 7 and laser therapy in 5. Dermatology Life Quality Index (DLQI) at baseline was 8.4, at 1 month was 2.8 and at 12 months was 2.4. Adverse effects were hyperpigmentation in 6, teleangiectasia in 2, ulceration in 1 and systemic side effects in 1 patient. The difference was significant (P< 0.05). Conclusion: The efficacy and safety of the combination of 5-FU and TAC in keloids found be beneficial.